The town got its name from Amfissa who, according to myth, was a mistress of the god Apollo and the daughter of Macar, a son of Aeolus.
In 338 B.C., Amfissa was destroyed by Philip II of Macedonia who had been called upon by the Amphictyonic League during the Third Sacred War. He demolished the city and wrecked its acropolis as punishment because the Amfissians had cultivated land on the Crissaean plain, which belonged to Delphi and the Amphictyonic League.
During the 13th century A.D., the city was known as Salona. Its name most likely came from the Frank family de Chalons, members of which ruled the area.
(source & copyright: learn more at theDelphiGuide.com)